Gout is a common form of arthritis that is caused by high levels of uric acid, a chemical produced by the breakdown of tissues in the body and present in certain foods and drinks.
Acute gout, or a gout attack, occurs when something causes uric acid levels to rise or pushes crystals that have formed into the joint, causing an attack.
The inflammation and resulting pain usually attack at night and intensify over the next 8 to 12 hours.
"The findings suggest that gout attacks are associated with a transient increase in cardiovascular distress after the attack," said lead study author Professor Abhishek of Nottingham Medical School.
At high levels, uric acid deposits in the joints and forms needle-like crystals around them. When "broken off" from the deposits, these crystals cause severe inflammation that manifests as joint pain, swelling, redness, and tenderness that often lasts 1-2 weeks. These episodes, called gout attacks, often recur. Inflammation is also a risk factor for heart attack and stroke.
In the study published in the journal JAMA, the team used data from 62,574 gout patients treated by the National Health Service in Great Britain.
Of the total, 10,475 suffered a heart attack or stroke after being diagnosed with gout, while others of a similar age, half and roughly the same age as those suffering from gout, did not experience such dangerous conditions.
Patients with gout who died of a heart attack or stroke were more than four times more likely to have had a joint-related attack of the disease in the previous 0-60 days and more than twice as likely were likely to have developed gout in the previous 61 years.
"People who have repeated gout attacks should be treated for a long time with medications and treatments to lower uric acid. This is a reliable way to remove urate crystal deposits and eliminate the risk of gout. It is also recommended that these patients take anti-inflammatory drugs for the first few months, as urate-lowering treatments can cause gout flare-ups in the short term," said Abhishek.
"Persons suffering from gout should adopt a healthy lifestyle and control high blood pressure, cholesterol, obesity and diabetes in order to minimize the risk of heart attack and stroke," explained the doctor.