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Biological age and health problems if it turns out to be too high

2024-05-29 12:14:25Lifestyle SHKRUAR NGA REDAKSIA VOX

Biological age and health problems if it turns out to be too high

A discrepancy between your biological age and that shown on your ID card could mean an increased risk of developing a stroke or a form of dementia. This is suggested by the results of a study by the Karolinska Institute (Sweden) published in the Journal of Neurology, Neurosurgery and Psychiatry.

The gap between chronological age and the body's actual aging appears to constitute, by itself and other genetic, socioeconomic, and equal lifestyle factors, an important element in determining a person's neurological health.

Traditionally, chronological age has always been considered to determine the risk of chronic or acute diseases that increase with age, such as cancer, cardiovascular problems and neurological disorders. But since we don't all age at the same rate, this indicator isn't necessarily as accurate and reliable.

Swedish researchers calculated the biological age of around 325,000 people whose data was recorded in a major British health database, Biobank UK. Subjects were between 40 and 70 years old at the time of the first measurement.

The biological age of each person (that is, the value that shows how well the body works) is calculated by taking into account 18 biomarkers, i.e. biological indicators such as the level of lipids or sugars in the blood, blood pressure, lung function, body mass index the body. Scientists analyzed the relationship between these values ​​and the risk of developing neurological diseases (vascular dementia, ischemic stroke, Parkinson's disease, amyotrophic lateral sclerosis or ALS) in the next nine years.

A biological age higher than chronological age has been associated with a (much) increased risk of developing dementia, especially vascular dementia, due to a reduction in blood flow to the brain, as well as causing an ischemic stroke (death of part of the brain tissue due to temporary lack of blood and oxygen in the brain).

The gap doesn't have to be huge: "If a person's biological age is five years older than their actual age, that person has a 40% higher risk of developing vascular dementia or having a stroke, ” says Jonathan Mak, co-author of the study. There is also an association between advanced biological age and a much rarer diagnosis, ALS, but not between advanced biological age and Parkinson's.

The study is limited to discovering a link between biological age and diseases, without establishing a cause-and-effect relationship. The interesting fact, however, is that many of the bioindicators that determine biological age can be controlled through medication or lifestyle: it will be important to find out if reducing biological age can delay the development of the listed neurological problems.


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