People with type A blood may be at higher risk of having a stroke before the age of 60 compared to other blood types, researchers have found.
So those with blood type O are less likely to have such a stroke.
The research was conducted by a team led by scientists from the University of Maryland School of Medicine in the United States, who looked at the link between genetic characteristics such as blood type and their relationship to stroke.
To do this, they looked at data from 48 genetic studies on ischemic stroke in adults between the ages of 18 and 59.
Strokes are caused by a blockage of blood flow to the brain.
In total, the studies included about 17,000 stroke patients and nearly 600,000 healthy controls who had never experienced a stroke.
"We were interested in trying to identify the genetic determinants of stroke," study principal investigator Braxton Mitchell told Euronews.
Humans have four main blood types, A, B, AB, and O, and a person's blood type is determined by the genes they inherit from their parents.
What the researchers found was that those who had a stroke at a young age were those with blood type A and less likely to have blood type O, compared to people who had never had a stroke.
"Having blood type A increases the risk by about 16 percent for early stroke," Mitchell said.
"If you have blood type O, you are 12 percent less likely to have a heart attack, compared to only 4 percent less likely to have a subsequent heart attack."
They point out that those with type A blood do not need to worry about having an early stroke, or getting involved in extra screening.
"Clinically, we don't have to worry about our blood types putting us at high risk for stroke," Mitchell said.
"There are other risk factors for stroke that are much more important, such as hypertension and smoking. So if we want to reduce the risk of stroke, these are really the factors we need to pay attention to."
It's still unclear why blood type A confers this higher risk, but researchers think it may have something to do with blood clotting factors.
Other studies have suggested that those with type A blood have a slightly higher risk of developing blood clots in the legs, known as deep vein thrombosis.
Blood type linked to risk of other conditions
A study by scientists from the Harvard School of Public Health found that people with blood types A, B or AB have a higher risk of coronary heart disease than people with blood type O.
Those with the rarest blood type, AB, had the greatest risk.
Other studies have suggested that people with blood type A have a higher risk of stomach cancer, compared to those with other blood types.
'Big step' towards helping to reduce stroke risk
Commenting on the findings, Clare Jonas from the UK Stroke Charity said the results were a "huge step" towards better monitoring of risk factors for early stroke.
"Most strokes occur in older people, for reasons we are usually aware of such as high blood pressure, thickening of the arteries or atrial fibrillation," said
Jonas, who is Head of Communication and Engagement Research at the Stroke Association.
"The causes of stroke in younger adults are not well understood, making it more difficult to prevent," she said in a statement.
"We don't yet know why people with blood type A may be at increased risk of early stroke. This means we cannot yet develop targeted prevention for early stroke."