At least 10 people have been killed and 15 others injured in a knife attack in Canada's central Saskatchewan province, police say.
The victims were found at 13 sites on the James Smith Cree Nation and the nearby village of Weldon.
A couple Damien Sanderson and Myles Sanderson are on the run and are considered armed and dangerous.
Residents have been told to shelter in place as searches continue across a large geographic area.
"Stay safe! Be careful allowing others into your residence,” the Royal Saskatchewan Police (RCMP) tweeted.
Checkpoints have been set up, while the police identify travelers and drivers have been asked not to pick up hitchhikers.
A state of emergency has been declared in the James Smith Cree Nation, an indigenous community of about 2,000 people northeast of Weldon, where about 200 people live.
And a dangerous person alert was sent to all cell phones throughout the provinces of Saskatchewan, Manitoba and Alberta, a region almost half the size of Europe.